![]() ![]() This makes them one of the most friendly options for those who prefer a vegan or vegetarian option. With a dosage of 200mg per day and a 60-day supply, this option falls right in the middle for those looking for the most accurate dosage to take per day.īeing NON-GMO, certified, gluten-free certified, they are one of the few supplements that can claim these distinctions. Though relatively unknown, SmokyMountain Nutrition prevails as a good DIM supplement option. This could prove to be a little tedious for some. The only drawback of this particular option is the dosage required for the effective use of DIM.Īs the optimal usage is quite minimal compared with other supplements, those who choose BulkSupplements will need a scale to measure the correct amount. Bulk Supplements DIMįor those wanting the purest DIM option possible, this will be the most reliable. Zhou provides not only DIM, but broccoli seed extract, vitamin C, and vitamin E as well. Unlike some of the other supplement options, they have chosen to take a more scientific approach to their formulation. While it is not a prominent name in the supplement and healthcare industry, Zhou, has an interesting approach to DIM supplements. While this does make it less appealing for strict vegetarians, those looking for a minimalist formula will be happy. In terms of ingredients and purity, this supplement has very little added to it and only includes rice flour and gelatin. We Like Vitamins DIM provides a realistic dosage amount with a high amount of purity. We Like Vitamins provides a supplement that may be on the lower dosage end but has a purity that competes with higher-dose options available. With vegetarian-friendly capsules, and a gluten-free, organic manufacturing process Nutricost DIM is by far one of the most superior products on the market today. Nutricost’s 3rd party tested DIM supplement delivers a dosage on the higher end of the recommended usage with 300mg, but also has 5mg of BioPerine for increased absorption and bioavailability. ![]() We conclude that BR-DIM is well tolerated at single doses of up to 200 mg, and that increasing the dose to 300 mg did not result in an increase in C(max).Diindolylmethane (DIM) is a natural substance produced in your gut after eating cruciferous vegetables such as broccoli and has been shown to be an effective treatment for chronic diseases ( 1, 2).ĭIM has started picking up steam as a supplement of choice to deal with a variety of issues such as acne, PMS, mood swings, fibroids, menopause symptoms, and even things like man boobs. DIM restores healthy hormone balance by adjusting the balance of bad estrogens to good estrogens, and it blocks aromatase, which converts testosterone to estrogen. ![]() The single 300-mg dose of BR-DIM resulted in a mean C(max) of 108 ng/mL and a mean AUC of 532 h ng/mL. The single 100-mg dose of BR-DIM resulted in a mean maximum plasma concentration (C(max)) of 32 ng/mL and a mean area under the curve (AUC) of 128 h ng/mL, and a single 200-mg dose produced a mean C(max) of 104 ng/mL and a mean AUC of 553 h ng/mL. Analysis of serial plasma samples showed that only one subject at the 50-mg dose had detectable concentrations of DIM. Only the latter effect was judged as probably related to the study agent. At the 300-mg dose, one of six subjects reported mild nausea and headache and one also reported vomiting. No BR-DIM-related adverse effects were reported at doses up to 200 mg. The doses administered were 50, 100, 150, 200, and 300 mg, with the 300-mg dose repeated in an additional group. After randomization, one subject in each group received placebo whereas three received active BR-DIM. ![]() Groups of four subjects were enrolled for each dose level. We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in drug-free, non-smoking, healthy men and women. The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM). ![]()
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